New trend of the hottest drug packaging

2022-08-21
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New trend of drug packaging

drug packaging is becoming the most active branch of packaging products in China. China's accession to the WTO and the entry of more international pharmaceutical enterprises into China have intensified the competition in China's pharmaceutical industry, but improved the technical standards of the entire industry. Both western medicine and traditional Chinese medicine are innovating in packaging. Drug packaging is becoming the product with the best benefit and the highest technical content in the packaging industry

last year, the Beijing International Packaging Exhibition and the pharmaceutical exhibition were held at the China International Exhibition Center in Beijing at the same time. The foreign pharmaceutical packaging manufacturers in the pharmaceutical exhibition were more unexpected than those in the packaging exhibition, and both the exhibition area and the exhibition equipment were more and more sophisticated. This shows the current hot degree of pharmaceutical packaging in China. There is indeed a large overall gap between China's pharmaceutical product packaging and developed countries. There are two main reasons for this gap; First, the overall level of China's pharmaceutical industry is relatively low. For a long time, western medicine products in China are mainly imitations, and there are few self-developed products. The technology of traditional Chinese medicine production enterprises is obsolete, and similar products lack unified standards, which restricts the development; The second is the drawbacks of the drug circulation system. Drugs are mainly sold in hospitals for a long time, and there is no distinction between prescription and over-the-counter drugs. Drugs sold in pharmacies only account for a small part of the total. This system restricts the development of drug packaging and keeps the drug packaging old for a long time. With the reform of China's medical system, this situation has undergone a fundamental change. At present, almost all of the world's top 100 pharmaceutical enterprises have established joint ventures or wholly-owned pharmaceutical enterprises in China, which not only brings more new drug varieties, but also advanced pharmaceutical packaging concepts and standards. In terms of sales, it is inevitable that China's medicine will be separated. The drugstores springing up in various cities are the best proof of this change. The reform of sales mode has made drug packaging more emphasis on convenience and advertising than ever before, in addition to its hygienic and protective functions; And the fierce market 4. The expanding browsing competition of bursting strength testing machine also puts forward higher requirements for the cost control of packaging

taking advantage of the reform of the medical system, China's drug packaging is undergoing rapid changes

western medicine tablets and capsules will be mainly packaged with blisters

western medicine tablets are the drug dosage forms with the largest variety and sales volume. Large capacity glass bottles and brown bottles are rapidly withdrawing from this field, replaced by plastic bottles and aluminum-plastic blister packaging, which is becoming the most important form of tablet packaging. Although blister packaging is significantly better than bottled drugs in terms of convenience of carrying and dosage preparation, for a long time, "the unit cost of blister packaging is significantly higher than that of bottled drugs due to the large single dosage of drugs in China.". With the development of drug slow-release technology, blister packaging is gradually emerging

drug slow-release technology is to make the drug properties of a tablet release continuously for 12 hours or even longer. Its appearance has greatly reduced the dosage of drugs. In order to maintain the concentration and duration of drugs in the body, the most common dosage of drugs used to be two to three tablets at a time, three to four times a day. Now one tablet at a time, once or twice a day can be taken. Many drugs require only 6 tablets in a course of treatment. Dose reduction has greatly narrowed the gap in the packaging cost of drugs

in addition to Western tablets, blister packaging is also the main packaging form of powder capsules, which also benefits from the development of sustained-release technology. Blister packaging will be the largest drug packaging form in the next few years

compared with bottled drugs, the biggest advantage of blister packaging is that it is easy to carry, and it can reduce the pollution in the process of carrying and taking drugs. At present, the latest development of blister packaging is to scratch the bottom plate of blister packaging, so that each drug can be easily separated. Some pharmaceutical companies also printed on the back of the drug for a week to remind patients with 5 The sample is broken and the latter is taken, which truly achieves humanized design. The basis of this technology is the accurate positioning of printing and molding

drug cartons have larger marking space

blister packaging usually uses cartons as outer packaging. Compared with bottles, the carton outer packaging has more room to play in the taking instructions and decoration design of drugs. In order to improve the use safety of drugs and meet the anti-counterfeiting requirements, the outer packaging carton will adopt more destructive opening design. With the improvement of the management level of pharmaceutical enterprises, the technology of coding and identifying each batch of drugs will be more applied to packaging, such as setting a group of codes for each group of drugs to ensure that the products can be accurately recalled in case of problems

in addition, famous pharmaceutical manufacturers attach great importance to the identification unity and inertia of outer packaging cartons. The typical practice is to set a special color on the package of each drug, and design a unified font and trademark position on the outer packaging carton. Such a drug packaging design mode will be popularized among domestic pharmaceutical enterprises

on packaging machines, fully automatic blister packaging machines will be used more and more. This machine includes the forming of blister, filling and sealing of drugs, forming of outer packaging carton, folding and inserting of instructions, entering of blister plate and sealing of carton, and the whole process is completed at one time. The filling and sealing of drugs need to be completed in a GMP compliant environment. In addition to the high degree of automation, the advanced model is loaded with a number of safety detection devices. Including the identification and detection of packaging boxes and instructions, which can greatly improve the safety and reduce the misloading of drugs

in order to reduce the possibility of children taking drugs by mistake, foreign drug packaging also has certain requirements in terms of packaging tear strength, bottle cap twist strength, etc., and there are some interesting packaging design forms for children's drugs

Chinese patent medicine

traditional Chinese medicine is the treasure of Chinese traditional culture, but the proportion of Chinese traditional medicine in the international market is very low. This is related to the insufficient development of Chinese patent medicine in China. In addition, there are two main reasons: first, there is no clear definition and standard for the origin and effective ingredients of Chinese traditional medicine. Moreover, some Chinese patent medicines contain protected animals and plants, which restricts the export; Second, the preparation of Chinese patent medicine is backward. Generally, the dosage of Chinese patent medicine is too large, which is very inconvenient. Therefore, to improve and improve the level of Chinese patent medicine preparations, Western preparation of traditional Chinese medicine is one of the ways out for traditional Chinese medicine

tablets, capsules, water needles and oral liquids will be the most important dosage forms of traditional Chinese medicine in the future. Blister packaging, curved neck ampoules and controlled oral liquid bottles will be the main packaging methods, and the proportion of honey pills will gradually decrease. The packaging technology and equipment used by western medicine will be more used by Chinese patent medicine

due to the high price of some high-end traditional Chinese medicine, there will be expensive packaging forms

famous traditional Chinese medicine manufacturers will pay more attention to brand publicity and image consistency on packaging

in addition, the packaging of traditional Chinese medicine slices will also be more refined. Medium and high-end herbal medicines will appear in small and medium-sized packaging forms such as vacuum packaging or modified atmosphere packaging, and cartons as outer packaging will also be more popular

the export of traditional Chinese medicine as raw materials will change with the development of Chinese patent medicine. The use of raw materials and labeling of exported Chinese patent medicines will be more in line with international norms. Many protected animals and gear rods have oil and dirt, or the upper limit plate of the gear rod is pressed too tightly. Poisonous plants will be replaced by other raw materials

injection

the use of disposable plastic syringes has brought a great change to the packaging and application of injections in China

at present, the latest development is to use pre filled packaging on some injections, that is, the drugs are pre filled into the syringe, and the needles are directly applied when used. This kind of products will first be applied in vaccine and other industries, with the advantages of accurate dosage, convenient use, minimizing medication errors, and little drug damage during use

this kind of pre filled injectable drugs are usually produced by professional manufacturers, including syringes, pushers and needles, which are packed aseptically and filled in the pharmaceutical factory. It is stored and sold after aseptic packaging, and the shelf life is equivalent to that of traditional drugs

the needle can be made of glass or plastic

although the commonly used ampoule is still the most commonly used packaging form for injection liquid, it will be replaced by other forms of packaging sooner or later because glass chips are easy to fall into the liquid when used

large infusion

large infusion is one of the most active areas of drug packaging reform in China at present

due to the national implementation of GMP, the number of pharmaceutical factories producing large infusion has been reduced from 390 to more than 200, and the production is more centralized. At present, the major infusion production enterprises in China are Shuanghe pharmaceutical, Huarui, Fresenius, Otsuka, etc

last year, the annual output of large infusion in China was about 3billion. Most of them are packaged in glass bottles, accounting for more than 80% of the national market. At present, there are two directions for the improvement of large infusion packaging - composite flexible packaging bags and plastic bottles

at present, these two packaging forms are used abroad, and flexible packaging infusion bags have been developed in China. Although the PVC soft bag, known as the second generation infusion container, solves the air pollution problem of the original bottled semi open infusion, its PVC material itself has permeability and permeability, which makes sterilization difficult. At present, the latest packaging material widely used in the world is non PVC folding composite soft bag. Although it is also used by domestic pharmaceutical enterprises, because the raw materials of this product cannot be produced domestically and the price is high, it does not adapt to the basic medical insurance system of "low level and wide coverage", so it seems that there will be no great development in the short term

Otsuka, Japan, is the first foreign pharmaceutical enterprise approved to establish a pharmaceutical joint venture in China. As early as 1984, a large infusion production line of 50011:11 polypropylene plastic bottles was built in Tianjin, with an annual output of 6million bottles. After nearly 20 years of delay, a new round of capital increase and expansion began in 2000, so that the output of large infusion reached 20million bags. Its goal is flexible packaging. However, insiders generally expressed doubts about this practice. Because as the competition of large infusion products intensifies, the price war will also be inevitable, and the high cost will make it lose the opportunity to seize the market

Shuanghe pharmaceutical is the largest infusion manufacturer in China at present, with an output of 800million bottles, far ahead of similar domestic pharmaceutical enterprises. Anhui Shuanghe is the main infusion production base of Shuanghe pharmaceutical. After the new infusion production workshop of the factory is put into use in October this year, the output will reach more than 200million bottles, of which 60million bottles will use PP bottles. This will be the first large-scale use of BOPP bottles for infusion packaging in China. Due to the requirements of hygiene, the material used for large infusion bottles is currently limited to polypropylene. Although this form of packaging has long been used abroad

different from the use of glass bottles, PP bottles cannot be purchased because they cannot be cleaned twice, and the hygiene requirements for bottle production are extremely strict. They must be produced in plants that meet GMP requirements, and the storage conditions must also meet GMP requirements. This actually requires that bottles must be produced in the same factory as the pharmaceutical factory. In addition, the production equipment of infusion pharmaceutical PP bottles is also different from that of beverage bottles. For example, most parts need to be chrome plated

Anhui Shuanghe has ordered two PP bottles produced by Hong Kong environmental protection group this year

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